• br Results br Discussion Our studies highlight

  2018-11-08

  

  Results Discussion Our studies highlight the potential clinical significance of the iC9 safeguard system. Recent studies introducing suicide gene-based safeguard systems into mouse or rhesus iPSCs report that teratoma formation was significantly delayed or inhibited only when treatment started

• br Experimental Procedures Detailed information on the

  2018-11-08

  

  Experimental Procedures Detailed information on the experimental procedures can be found in the Supplemental Information File. Author Contributions Introduction Although cell-fate decisions are fairly stable in vivo, somatic inhibitor of apoptosis proteins can be reprogrammed back into plu

• br Results br Discussion This study describes

  2018-11-07

  

  Results Discussion This study describes a simplified protocol for the efficient generation of hiNSCs via direct reprogramming. hiNSC lines grow as colonies on MEF feeder layers. Like hESCs, hiNSCs stain positive for pluripotent transcription factors OCT4, SOX2, and NANOG, but do not express ce

• Introduction A transparent cornea is

  2018-11-07

  

  Introduction A transparent cornea is crucial for optimal vision. Ocular trauma, a leading cause of loss of corneal transparency, accounts for approximately 25 million cases of blindness annually (Resnikoff et al., 2008; Whitcher et al., 2001). During ocular injury, inflammation-induced transforming

• The specific sources of data for each

  2018-11-07

  

  The specific sources of data for each section of the paper are described in Appendix A. Results Discussion From the above observations we draw a series of ten inferences, presented roughly in the order of those least to most speculative; since we have offered no identification strategy in the

• Parks serve as destinations for

  2018-11-07

  

  Parks serve as destinations for dog-walkers, and dog-walking routines support physical activity (Cutt, Giles-Corti, Knuiman & Burke, 2007; Christian et al., 2013). Dogs may provide motivation for people to remain active, when built environment (e.g., low walkability) and weather conditions might oth

• br Theoretical foundation of the study br

  2018-11-07

  

  Theoretical foundation of the study Methodology A Web-based survey was distributed to 3060 international and/or general manager in charge of the firm\'s foreign business activity of Spanish exporting firms in the food sector, beverage sector, consumer goods, raw materials, industrial products

• Single channel A A EEG

  2018-11-07

  

  Single-channel A1-A2 EEG and automated sleep staging algorithms have recently demonstrated high agreement rate with PSG [6]. Abbreviated montages for sleep staging have also been successful [7] and it is thus conceivable that other single-channel locations could also perform well in algorithmic slee

• br Materials and Methods br Results

  2018-11-07

  

  Materials and Methods Results Discussion Although widely accepted as a prognostic biomarker in advanced CRC, our findings in this study clearly showed that EGFR protein expression was dramatically elevated in colonic adenomatous polyps in FAP patients, even at a very early stage. More impor

• Based on the original discoveries the S

  2018-11-07

  

  Based on the original discoveries, the S2R has been authentically defined as a high-affinity DTG binding site with a molecular weight at 18–21kDa (Bowen et al., 1989; Hellewell and Bowen, 1990; Hellewell et al., 1994; Itzhak, 1987; Weber et al., 1986). According to this definition, the results prese

• crf hormone The response to self or

  2018-11-07

  

  The response to (self or non-self) crf hormone restricted by similar class II MHC molecules leads to a usage of a limited number of rearrangements of the Beta chain of the TCR, shared among several patients, with common variable-diversity-junctional segments (V-D-J) and similar three-dimensional str

• ARMS KIDINS carriers showed a picture consistent with low

  2018-11-07

  

  ARMS/KIDINS220 carriers showed a picture consistent with low borderline intelligence and diminishing education and employment over earlier ages are inferred, since each completed at least one year of college (excluding dual-hit cases). While they showed the second slowest processing speeds after the

• br Authors Contributions br Acknowledgements We thank the

  2018-11-07

  

  Authors\' Contributions Acknowledgements We thank the EpiGen Operational Management Group for their project management and Dr. Irma Silva Zolezzi, Nestlé Research Center, for helpful discussion of the manuscript. We also thank all the families that took part in The Raine study and the Raine St

• br Telomere Dysfunction Can Occur Irrespectively of Length S

  2018-11-07

  

  Telomere Dysfunction Can Occur Irrespectively of Length So far, the majority of studies have given evidence to senescence as a result of telomere shortening. However, several reports now suggest that telomere dysfunction can also occur in a length-independent manner (Fig. 1). For example, persist

• Although these data indicate the potential effectiveness of

  2018-11-07

  

  Although these data indicate the potential effectiveness of passive immunotherapy by NAbs, the successful development of preventive HIV-1 vaccines requires a thorough understanding of how Nabs are induced during HIV-1 infection. The unusual maturation features of NAbs make them extremely difficult t

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