• PSA NCAM targeted cell sorting from neural

  2018-10-24

  

  PSA-NCAM-targeted cell sorting from neural rosettes allowed an isolation of NCSC populations. Compared to the previously defined hPSC-derived NCSCs, p75+/HNK1+ cells, PSA-NCAM− p2y inhibitor exhibited similar molecular characteristics and multipotentiality; i.e., both were able to generate ectoderma

• This study indicates that miR and miR may also be

  2018-10-24

  

  This study indicates that miR-124 and miR-219 may also be involved in the neurogenesis-to-gliogenesis switch by NSPCs. miR-124 promotes neurogenesis via downregulation of several genes (Sox9, Scp1, and Ezh2) that are positive regulators of gliogenesis or negative regulators of neurogenesis in the de

• Introduction The correct functioning of the epigenome ensure

  2018-10-24

  

  Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

• Recently we found that vesicular monoamine transporter

  2018-10-24

  

  Recently, we found that vesicular monoamine transporter 2 (VMAT2) regulates monoamine (including dopamine) storage by acting as a negative regulator, such that high monoamine levels inhibit the progression from Pdx1+ pancreatic progenitor glucokinase inhibitor to Neurog3+ endocrine progenitor cells

• Whether LIF contributes to differentiation inhibition in rab

  2018-10-24

  

  Whether LIF contributes to differentiation inhibition in rabbit PSCs is unclear. LIF and FGF2 cooperatively support self-renewal in ESCs derived from parthenogenotes and propagated in feeder-free conditions, but the effect of LIF is modest (Hsieh et al., 2011). In this study, AKSL and AKSgff cell li

• G lucidum is a medicinal mushroom well known for

  2018-10-24

  

  G. lucidum is a medicinal mushroom well known for its legendary anti-aging benefits. Our findings that GLP not only promote NPC proliferation but also reduce amyloid deposits provide potential underlying mechanisms of its anti-aging effects. Extract of G. lucidum has also been reported to inhibit th

• br Results br Discussion We

  2018-10-24

  

  Results Discussion We successfully achieved quick induction of apoptosis in approximately 95% of the iPSCs in vitro, as in a previous report (Ando et al., 2015). This apoptosis induction rate was essentially comparable with the data reported from experiments carried out using the HSV-TK system

• br Results br Discussion PSC

  2018-10-24

  

  Results Discussion PSC offer great opportunities for human health, allowing the derivation of patient-specific tissues and providing disease models for drug screening. Thus, investigation of factors and mechanisms that regulate pluripotency constitutes a rapidly growing area of cutting-edge re

• BKM 120 br Distinguishing features of and

  2018-10-24

  

  Distinguishing features of, and selected tensions within, a model-based perspective A model-based perspective emphasizes the processes producing outcome variation, and observed data are used to characterize that data-generating process. This is the majority perspective in statistical textbooks, i

• Systematic reviews of the literature have identified some

  2018-10-24

  

  Systematic reviews of the literature have identified some consistent physical environment correlates of physical activity, including land use mix, connectivity and residential density which all have positive associations with activity (McCormack & Shiell, 2011; Saelens & Handy, 2008). Access to gree

• We are particularly interested in how

  2018-10-24

  

  We are particularly interested in how socioeconomic status (SES) is associated with multimorbidity earlier in the lifecourse. Low SES has been linked to greater occurrence of numerous individual chronic conditions, including hypertension (Vargas, Ingram, & Gillum, 2000) heart disease (Thurston, Kubz

• One respondent could report up to three illness episodes

  2018-10-24

  

  One respondent could report up to three illness episodes in our survey, including one acute “severe” illness, one acute “mild” illness, and one “long-term, recurrent, or chronic” condition. The severity of the acute illness episodes (“mild” or “severe”) was based on the respondents’ self-assessment;

• Although technological improvements in terms of specimen acq

  2018-10-23

  

  Although technological improvements in terms of specimen acquisition and processing have been made, much work remains to be done to ensure the quality of biospecimens and harmonization of tissue collection, processing and storage procedures, attributable largely to the long-standing success of forma

• Here we found that podocytes

  2018-10-23

  

  Here we found that podocytes, both in vitro and in kidney-biopsy tissue sections, express CAII. Furthermore, IgG4 purified from the patient\'s serum elicits early intracellular acidification with profound effects on podocyte homeostasis as a likely consequence of the interaction of IgG4 autoantibodi

• An ideal assay would measure the

  2018-10-23

  

  An ideal assay would measure the frequency of latently infected CD4+ T THZ2 without relying on the amplification of viral replication, which is difficult to control and requires at least a week of cell culture. Measuring the production of viral particles in culture supernatants of stimulated cells

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