• It is important to know whether pilsicainide can be

  2019-05-06

  

  It is important to know whether pilsicainide can be used as a therapeutic agent for LQT2 patients; and if so, we should determine the types of LQT2 mutation carriers to whom pilsicainide could be administered. As shown in Fig. 8, we examined the effects of pilsicainide on two mutant hERG proteins, G

• Even with the limitations in the available data on DALYs

  2019-05-06

  

  Even with the limitations in the available data on DALYs, the funding gap is huge. The Research Investments in Global Health study analysed public and philanthropic infectious disease research awards to UK institutions (1997–2013), and compared them to the burden in DALYs, describing a new metric o

• Al observar las cuatro constituciones

  2019-05-06

  

  Al observar las cuatro constituciones (Brasil, Argentina, Paraguay y Uruguay) se destaca una ejemplar redacción del Artículo 47 de la Constitución de Uruguay, al definir cuál es la prioridad en el uso del recurso además de determinar no sólo la participación social en la planificación de estrategia

• In MM the optimal sequence or

  2019-05-06

  

  In MM, the optimal sequence or combination of the different therapeutic regimens available remains unclear and information is needed on the efficacy of each treatment after various prior therapies. Although a substantial number of different regimens and schedules were used for the treatment of first

• Cabe mencionar que en despu s de diez

  2019-05-05

  

  Cabe mencionar que, en 2005, después de diez años de trabajar en la Universidad de Pittsburgh, espacio de gran relevancia para la gestación de las antologías analizadas, Moraña se trasladó d-tubocurarine la Universidad de Washington en St. Louis, donde, hasta la fecha, pasó a fungir como profesora y

• A type saddle back type

  2019-05-05

  

  A type 2 (“saddle-back type”) or type 3 ST-segment elevation cannot substitute for a type 1, unless converted to type 1 with fever or sodium drug challenge. A drug challenge–induced type 1 can be used to diagnose BrS only if accompanied by 1 of the criteria specified above. Type 2 is characterized b

• FGF is a member of the FGF family It is

  2019-05-05

  

  FGF21 is a member of the FGF family. It is preferentially expressed in the liver and is inducible in adipose tissue. As an insulin-sensitizing metabolic regulator, it stimulates 3-Methyladenine manufacturer uptake by adipocytes and also targets the central nervous system. FGF21 treatment corrects d

• Hill and colleagues estimate that globally

  2019-05-05

  

  Hill and colleagues\' estimate that, globally, about 1·5 million (95% CI 1·2–1·8) children aged 5–14 years died in 2010. This finding is somewhat higher than the total estimated by the UN of 1·3 million, although the UN estimate is within the investigators\' CI. However, their estimate is 87% higher

• br It is encouraging to read in

  2019-05-05

  

  It is encouraging to read in the Article by Mercy Kanyuka and colleagues (March, 2016) about Malawi\'s success in reducing child mortality, but I fear the authors might have missed one of the key factors contributing towards this great achievement. Specifically, that Malawi is unique in sub-Sahara

• br Conflict of interest br

  2019-05-04

  

  Conflict of interest Acknowledgment Introduction Several investigators recently showed that the superior vena cava (SVC) was one of the major foci for initiating atrial tachyarrhythmias, such as atrial tachycardia (AT) and atrial fibrillation (AF) [1–4]. Conduction block between the atrium

• br Commentary Careful analysis of the electrocardiograph Fig

  2019-05-04

  

  Commentary Careful analysis of the electrocardiograph (Fig. 1) reveals narrow and similar QRS complexes in all the beats, showing that they are all intrinsic QRS complexes. Some intrinsic P waves are also visible at the ST-T segment (after R3, R7, R11, and R15); these are the beats without any sp

• Human ether a go go related

  2019-05-04

  

  Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium order q vd oph that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being translated i

• De hecho la Am rica po tica comparte con

  2019-05-04

  

  De hecho la América poética comparte con estos periódicos especializados un mismo receptor, una misma nómina de suscriptores que gustan de la poesía lírica, un mismo “público ilustrado e igualmente sensible XMU-MP-1 la razón del filósofo y al arte del poeta romántico” (Batticuore: 113). Estas revist

• However transparency has declined rather than improved A rec

  2019-05-04

  

  However, transparency has declined rather than improved. A recent analysis in the ranked PEPFAR as very poor—50th of 67 aid agencies worldwide. The report noted that, “PEPFAR does not disclose information on contracts to prime partners and sub-partners in a machine-readable and open format consiste

• protease activated receptor The excellent birth cohort study

  2019-05-04

  

  The excellent birth cohort study reported in by Heather Zar and colleagues, done in a periurban area outside Cape Town in South Africa, is a good example of a study that has provided important information about child pneumonia at a time of change. It provides the first incidence estimates of pneumo

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