• Carprofen In the past decade preclinical studies have addres

  2019-06-28

  

  In the past decade, preclinical studies have addressed the putative role of non-coding RNAs in tumorigenesis, metastasis and therapy response in osteotropic cancers. Besides long non-coding RNAs, microRNAs (miRs) represent a class of small non-coding RNAs, (18–25 nucleotides long), that regulate pro

• Finalmente la parcela y heredad patrimonial del vecindario d

  2019-06-28

  

  Finalmente, la parcela y heredad patrimonial del vecindario de Xolloco Acatla –objeto de estas acérrimas desavenencias desde 1613– recibió protección legal. El espacio en el que se ubicaba la antigua cruz se institucionalizó y se construyó la ermita de Santa Cruz Acatla, antecedente inmediato de la

• Leptin synthesized in adipocytes is a regulator of fat metab

  2019-06-28

  

  Leptin, synthesized in adipocytes, is a regulator of fat metabolism and reproduction [7]. The levels of leptin correlate with body fat mass and show a wide variation in individuals. In the bone marrow microenvironment, the leptin secreting adipocytes occupy a significant part [8]. Leptin stimulates

• br Discussion CML was the first

  2019-06-28

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• That well established data for Sapindaceae

  2019-06-28

  

  That well-established data for Sapindaceae toxicity have long existed from clinical experience in Africa and the Caribbean is an important lesson for global health and neurotoxicology. A worldwide understanding of the adverse effects on the nervous system of both naturally occurring as well as synth

• Introduction Brugada syndrome is severe arrhythmia character

  2019-06-28

  

  Introduction Brugada syndrome is severe arrhythmia characterized by specific ST elevations in precordial leads and sudden ventricular fibrillation (VF), and the condition may result in sudden cardiac death [1–5]. By implanting defibrillation devices, also known as implantable cardioverter-defibrill

• In the present study we found that stathmin

  2019-06-28

  

  In the present study, we found that stathmin was significantly down-regulated upon treatment with a combination of Zol and gefitinib. The down-regulation of stathmin, which was not detected by 2-D DIGE after treatment with either agent alone, was considered to be attributable to cooperative effect o

• br Materials and methods A retrospective questionnaire surve

  2019-06-28

  

  Materials and methods A retrospective questionnaire survey was conducted among 299 JHRS institutions from December 2012 to January 2013. Patients with persistent AF who underwent TEE for elective ECV were included. LA thrombus incidence, risk factors for thrombus formation as indicated by the CHA

• br Results Compared to the respective

  2019-06-28

  

  Results Compared to the respective untreated groups, the VT duration was shorter in clonidine-treated ETB-deficient rats during phase I and in wild-type rats during phase II (Fig. 1A). Heart rate (HR) increased in both untreated groups, but this response was blunted after clonidine, mainly in ETB

• br We appreciate the response by Sharath

  2019-06-28

  

  We appreciate the response by Sharath Nagaraja and Ritesh Menezes to our Comment, in which we had argued that patients with tuberculosis deserve a complete and patient-centric solution, irrespective of whether they seek care in the public or private health sector. Nagaraja and Menezes seem to have

• Previous studies have demonstrated localization

  2019-06-27

  

  Previous studies have demonstrated localization of miR-21 staining in stromal tool of OSCC associated with the tongue and mouth floor—this might be a useful prognostic predictor. We also observed miR-21 staining in the stromal cells of tumors. However, since multiple lines of evidence indicate the i

• br Discussion In our patient series coronary

  2019-06-27

  

  Discussion In our patient series, coronary angiography was performed routinely prior to electrophysiological study, revealing a 9.1% (5/55) incidence of significant coronary artery stenosis in patients with Brugada syndrome/Brugada-type ECG. Although acute myocardial ischemia has been reported to

• Calyculin A structure br Introduction Despite the widespread

  2019-06-27

  

  Introduction Despite the widespread use of bone-targeted agents in the care of patients with bone metastases from prostate and breast cancer, questions regarding the optimal; choice of agent, dose, dosing frequency, and duration of therapy remain unanswered [1–6]. Our research group is interested

• Cathepsin G Inhibitor I br Acknowledgements br Introduction

  2019-06-27

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• The coverage and quality of laboratory services throughout A

  2019-06-27

  

  The coverage and quality of laboratory services throughout Africa is inadequately documented. Quality provided by individual laboratories is questioned, and not all facilities are enrolled in external quality assurance schemes. For example, in 2013, an evaluation of accredited laboratories in sub-Sa

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