• G lucidum is a medicinal mushroom well known for

  2018-10-24

  

  G. lucidum is a medicinal mushroom well known for its legendary anti-aging benefits. Our findings that GLP not only promote NPC proliferation but also reduce amyloid deposits provide potential underlying mechanisms of its anti-aging effects. Extract of G. lucidum has also been reported to inhibit th

• br Results br Discussion We

  2018-10-24

  

  Results Discussion We successfully achieved quick induction of apoptosis in approximately 95% of the iPSCs in vitro, as in a previous report (Ando et al., 2015). This apoptosis induction rate was essentially comparable with the data reported from experiments carried out using the HSV-TK system

• br Results br Discussion PSC

  2018-10-24

  

  Results Discussion PSC offer great opportunities for human health, allowing the derivation of patient-specific tissues and providing disease models for drug screening. Thus, investigation of factors and mechanisms that regulate pluripotency constitutes a rapidly growing area of cutting-edge re

• BKM 120 br Distinguishing features of and

  2018-10-24

  

  Distinguishing features of, and selected tensions within, a model-based perspective A model-based perspective emphasizes the processes producing outcome variation, and observed data are used to characterize that data-generating process. This is the majority perspective in statistical textbooks, i

• Systematic reviews of the literature have identified some

  2018-10-24

  

  Systematic reviews of the literature have identified some consistent physical environment correlates of physical activity, including land use mix, connectivity and residential density which all have positive associations with activity (McCormack & Shiell, 2011; Saelens & Handy, 2008). Access to gree

• We are particularly interested in how

  2018-10-24

  

  We are particularly interested in how socioeconomic status (SES) is associated with multimorbidity earlier in the lifecourse. Low SES has been linked to greater occurrence of numerous individual chronic conditions, including hypertension (Vargas, Ingram, & Gillum, 2000) heart disease (Thurston, Kubz

• One respondent could report up to three illness episodes

  2018-10-24

  

  One respondent could report up to three illness episodes in our survey, including one acute “severe” illness, one acute “mild” illness, and one “long-term, recurrent, or chronic” condition. The severity of the acute illness episodes (“mild” or “severe”) was based on the respondents’ self-assessment;

• Although technological improvements in terms of specimen acq

  2018-10-23

  

  Although technological improvements in terms of specimen acquisition and processing have been made, much work remains to be done to ensure the quality of biospecimens and harmonization of tissue collection, processing and storage procedures, attributable largely to the long-standing success of forma

• Here we found that podocytes

  2018-10-23

  

  Here we found that podocytes, both in vitro and in kidney-biopsy tissue sections, express CAII. Furthermore, IgG4 purified from the patient\'s serum elicits early intracellular acidification with profound effects on podocyte homeostasis as a likely consequence of the interaction of IgG4 autoantibodi

• An ideal assay would measure the

  2018-10-23

  

  An ideal assay would measure the frequency of latently infected CD4+ T THZ2 without relying on the amplification of viral replication, which is difficult to control and requires at least a week of cell culture. Measuring the production of viral particles in culture supernatants of stimulated cells

• In the s to s

  2018-10-23

  

  In the 1970s to 1990s, serogroup W was a rare cause of meningococcal disease. In 2000, the first recorded serogroup W meningococcal disease outbreak occurred during the annual Hajj pilgrimage in Mecca, Saudi Arabia (Taha et al., 2000; Aguilera et al., 2002). The Hajj outbreak strain, referred to as

• To elucidate the mechanisms by which VEGFC CREB

  2018-10-23

  

  To elucidate the mechanisms by which VEGFC–CREB axis plays a role in vessel formation, we investigated the effect of VEGFC and hypoxia on NOTCH signaling. Our in vitro and in vivo findings indicate that both VEGFC and hypoxia stimulate DLL4–NOTCH1 signaling and these events require the activation of

• br Treatment decisions are generally based on MPN

  2018-10-23

  

  Treatment decisions are generally based on MPN subtype, risk category, age, and disease manifestations. For PV and ET, thrombosis risk category often guides the decision to use cytoreductive and anti-platelet therapies (and phlebotomy for PV). Historically, treatment of MF has been guided by the p

• Finally we advance some molecular

  2018-10-23

  

  Finally, we advance some molecular techniques such as host-pathogen RNA-seq, especially given the high GC content of Mtb, and the relative amounts of mammalian RNA to bacterial RNA: proverbial needles in a haystack. Host-pathogen RNA-seq has hitherto been discussed mainly as a theoretical possibilit

• br Approximately years ago new flavivirus was

  2018-10-23

  

  Approximately 70years ago, new flavivirus was discovered in the Zika forest of Uganda (). The eponymous virus is an arthropod-borne human pathogen that caused infrequent infections with relatively mild illness in Africa and received relatively little attention until recently. Over the last several

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